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What Devices for Vascular Interventions Are There?
Commonly used equipment for vascular interventional diagnosis and treatment provided by vascular medical device companies should include guide wires, catheters, balloon dilatation catheters, intravascular stents and stent-grafts, filters, and various puncture devices.
1. Puncture needles of vascular interventions: generally include ordinary puncture needles and special puncture needles
Ordinary puncture needles are further divided into single-wall puncture needles and trocar puncture needles. Generally, the length of the needle is 7cm, the diameter of the needle is 18-19G, and the guide wire of 0.015 in--0.038in can be inserted. Single-wall puncture needles are made of single-part stainless steel with a beveled tip and are mainly used for puncturing the anterior wall of blood vessels.
The trocar puncture needle is composed of an outer cannula and a needle core. At present, the commonly used needle cores are mostly hollow needles. The outer cannula is made of plastic, the puncture needle is inserted into the lumen of the blood vessel, the needle core is removed, the outer cannula is indwelled in the lumen, and then the guide wire is fed along the lumen of the outer cannula. It is often used for the puncture of common parts of peripheral arteries and veins.
Another micro-puncture trocar is mainly used for smaller arteries such as the brachial artery and radial artery. The diameter of the needle is 21G, and the 0,018in guide wire can be passed through the needle lumen. Special puncture needles mainly include atrial septal puncture needles (such as Brockenbrough puncture needles) and TIPSS special puncture needle sets, both of which are puncture devices with the cannula.
2. The choice of the guide wire for vascular interventions
The guide wire is the "pioneer" for entering human peripheral blood vessels. Its role is to:
① Import function;
② support function;
③ Open function;
④ exchange effect.
The surface of the guide wire currently used is generally covered with a hydrophilic film to ensure its lubricating passage in the lumen of the blood vessel. Often divided into ordinary (soft) guide wire, hardened guide wire, and special micro guide wire.
3. Selection of the catheter for vascular interventions
There are many types of catheters used for interventional diagnosis and treatment of peripheral vascular diseases, which can be divided into diagnostic angiography catheters and therapeutic catheters. Diagnostic angiography catheters can be further divided into selective angiography catheters and non-selective angiography catheters. Among them, commonly used non-selective angiography catheters are multi-hole pigtail angiography catheters and multi-sided hole straight-head angiography catheters. Its maximum flow rate can reach 20-25ml/s.
4. The selection of balloon catheters for vascular interventions
PTA therapy for peripheral blood vessels. All of them are designed with double lumen catheters. According to the size of the balloon, they can be divided into ultra-small balloons (diameter 2~5mm), ordinary balloons (diameter 5~10mm), and super-large balloons (diameter ≥12mm). At the same time, there are currently bare balloons and drug-coated balloons. Compared with ordinary balloons, the most special point of drug-coated balloons is that they can be loaded with drugs and can release effective drugs in a short time with the lesion. Therapeutic concentrations of the drug. In the treatment of specific diseases, it can keep blood vessels unobstructed for a longer time, reduce the occurrence of stenosis, and not leave any foreign bodies in the blood vessels, and the condition of preserving blood vessels provides more options for patients' follow-up treatment.
The Zylox UltraFree™ Drug-Eluting PTA Balloon Dilation Catheter is a carrier-free paclitaxel drug-eluting balloon. Compared with the existing drug-loaded balloons using drug carriers or excipients on the market, the pure drug ingredients of UltraFree™ PTA balloon catheters are safer, and also improve the drug-loading efficiency of the balloon coating. In addition, Zylox Medical's proprietary ultrasonic spray technology makes UltraFreeTM pure paclitaxel crystal particles smaller, more uniform, and more controllable. The drug absorption efficiency at the vascular target lesion is higher, and the drug effect is more durable. Animal experiments and clinical trials have fully verified the good safety and efficacy of UltraFreeTM drug-eluting PTA balloon dilatation catheter.
5. Selection of vascular stents for vascular interventions
The choice of the intravascular stent is mainly based on the lesion site, the diameter of the tube, and the length of the lesion. When applying endovascular stents to important vascular branches or branches, the ones with larger meshes should be used as far as possible, such as the bifurcation of the internal and external iliac arteries and veins, the branch of the subclavian artery near the vertebral artery, and the part where the hepatic vein joins the inferior vena cava, etc.
The diameter of the vascular stent should be about 10% or 1mm larger than the normal diameter of the implantation site. In this way, the stent can effectively maintain the patency of the lumen with its good radial expansion force.
Zylox ZENFLEX Pro™ Drug-Eluting Peripheral Vascular Stent System is the third peripheral drug-eluting self-expanding stent to be marketed in the world. It is a major milestone for domestic innovative medical devices to lead the international market. ZENFLEX Pro™ is based on the self-expanding stent ZENFLEX™, which has a unique helical architecture and micro-mesh design for excellent compliance and radial support. Innovative delivery system, precise stent release, comparable to world-class brand products. ZENFLEX Pro™ uses a similar polymer-free paclitaxel coating, and the low-concentration drug effect at the lesion site lasts for up to 180 days, effectively maintaining vascular patency, enabling doctors and patients to obtain better and longer-lasting therapeutic effects.
6. Selection of venous filters for vascular interventions
A metal device designed to prevent pulmonary embolism caused by continuous shedding of vena cava emboli. There are various configurations of filters to choose from. The selection of filters should be based on factors such as the shape of the vena cava, the diameter of the vena cava, the site of thrombosis, the course of thrombosis, and the age of the patient.
Zylox Tonbridge Medical is also building a comprehensive peripheral vascular device portfolio covering both arteries and veins, including stents, balloons, catheters, filters, and more. As of April 2022, 6 products of ZyloxMedical have obtained NMPA approval, and 5 products have obtained EU CE certification. In the future, we will continue to provide patients and doctors with more comprehensive and efficient products and solutions.